The Savikalpa Journal

The endocannabinoid system (ECS) plays a role in how the body regulates food intake and body weight. Studies have shown that individuals who consume cannabis have lower rates of obesity than those who have never consumed cannabis, as well as lower rates of diabetes.

When it comes to cannabis and insomnia, there is a long history of people utilising cannabis for better sleep. Since ancient times, people have noticed the sedating effects that come with some types of cannabis and have utilised it as a sleep aid.

Chronic pain is as real an ailment as any and is characterised by persistence. Defined simply, chronic pain is pain that is ongoing and lasts longer than 12 weeks.

Microdosing is the practice of taking a much smaller dose of a medication than is normally used. It’s a practice used with all kinds of compounds, but most often discussed with psychoactive substances such as LSD. Recently, people have started to apply the practice to cannabis and its popular ingredients, THC and CBD.

The effects of cannabis have a lot to do with the endocannabinoid system (ECS), which exists in all vertebrates and which plays a key role in regulating all types of crucial functions such as sleep, pain, and appetite.

Dysmenorrhea impacts nearly half the population of women, and in 10% of cases, symptoms can escalate to the extent of interfering with daily activities. 

Which is better, CBG or CBD? The answer depends on what you’re trying to achieve. CBG binds to various receptors, which can produce a range of effects in the body. For some conditions, like hypertension, CBG shows benefits that CBD doesn’t. In other cases, like controlling seizures, CBD is helpful, while the medical use of CBG isn’t.

Most often, drugs operate on one or two molecular targets in our bodies, creating a specific effect. A multi-target effect means plant compounds can operate on many targets. In cannabis, a popular example would be the interaction of THC with CB1, CB2, GPR18, GPR55, TRPV2, TRPV3, and many other receptors.

How serious is endometriosis? Common symptoms include pelvic pain and fatigue, with many women reporting a significant negative impact on their life, including on education, work, friendships, and sexual relationships. Learn how cannabis is helping manage symptoms of this often undiagnosed condition that affects millions worldwide.

Understanding what insomnia is, ways for symptom relief from insomnia, the treatment options for insomnia and more.

Septic arthritis develops quickly, often within hours. Key symptoms include intense joint pain that worsens with movement, swelling, redness, warmth, and fever. Patients may also experience fatigue and weakness.

THC is the main cannabinoid that is responsible for the psychotropic, euphoric effects of pot, or what people typically refer to as the “high.” People usually think about the benefits of a tolerance break and managing cannabis tolerance regarding THC. It works by activating a receptor in the central nervous system called CB1, part of the body’s endocannabinoid system (ECS).

Of course, using cannabis to treat gynaecological problems is nothing new in the world of cannabis and women’s health. Cannabis has an ancient tradition of being used as a medicine in obstetrics and gynaecology.. It’s been used historically to treat conditions like dysmenorrhea, dysuria, hyperemesis gravidarum, and menopausal symptoms.

What is titration? If you or someone you care for has recently been prescribed cannabinoid medicine, you’ve likely been introduced to the concept of titration. This might have been done through a cannabis dosage guide, or by your doctor providing dosage instructions that are perhaps a little more complicated than usual, considering cannabis tolerance is a little more complicated than usual.

In this brief explainer blog, we break down what the current laws governing cannabis are, and their likely evolution in the years to come.

Before any new medicine can be made available to the public, it must go through a series of steps to validate safety and efficacy – the fundamentals of a clinical trial.

Women’s health issues are widespread and incredibly diverse, affecting women across all ages and regions. Conditions like PCOS, PCOD, endometriosis, anaemia, and irregular periods are among the most common challenges faced by Indian women today.

Cannabis and CBD for stress relief are already a popular option for patients looking to relax, but how much do we know about how it works? Research tells us that the two most prevalent cannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD), reduce stress and anxiety through their interaction with the endocannabinoid system (ECS).

The ECS interacts with the hypothalamic-pituitary-ovarian (HPO) axis, managing and controlling key reproductive processes like helping eggs mature, pain modulation, the development of the uterus lining, implantation, the development of the embryo during pregnancy and more.

The researchers also found that cannabis flower “is an effective and fast acting antidepressant medication,” and that the THC levels “are the strongest independent predictors of symptoms relief among the product characteristics that are generally available to the public.”

Rheumatoid arthritis (RA) is a chronic autoimmune disease that mistakenly causes the body’s immune system to attack healthy joint tissue. Unlike regular arthritis that results from wear and tear, RA causes inflammation in the lining of your joints, leading to pain, swelling, stiffness, and, over time, joint damage. 

Better gut health is now understood to be a key determinant in disease prevention, not dissimilar to Ayurveda, which exhorts the primacy of the gut microbiome in maintaining health.

Using cannabis for several months is associated with a significant reduction in blood pressure among older adults with hypertension, correlating cannabinoids and blood pressure regulation, according to a prospective study published last week.

Modern pharmaceuticals, based on rigorous, peer-reviewed research and state-of-the-art development methods, make up the vast majority of the medicine used today. However, they have not managed to eliminate the time-tested plant-based healing and alternative natural remedies that have been trusted worldwide for centuries.

Research on cannabis-based treatments for diabetes and the endocannabinoid system and diabetes shows a strong connection between an overactive endocannabinoid system and the incidence of diabetes and obesity, and using cannabinoids tends to stimulate this system.

It’s true that 2-AG itself has anti-inflammatory actions within the brain, especially by interacting with CB1 and CB2 receptors. However, that isn’t the only role it plays in the inflammatory pathway.

There is scientific evidence suggesting that cannabis can reduce inflammation and may be able to help treat conditions that are either caused by inflammation or have it as a key symptom, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and hepatitis.

While some types of arthritis, such as rheumatoid arthritis or those with a genetic origin cannot be entirely prevented, certain lifestyle measures can help reduce the risk of developing or worsening arthritis.

Cannabis medicine has gained increased focus and importance in recent years concerning pain management and treatment. Not only is cannabis commonly sought out as an alternative to traditional pain medications, but also as a treatment option for conditions known to be treatment resistant, and more critically, as a tool to be used in opioid use reduction strategies and in reducing opioid related deaths.

What is Migraine? It is a neurological disorder causing intense, throbbing pain, often on one side of the head. Learn the difference between migraines and headaches, explore symptoms like nausea and light sensitivity, and discover effective treatments and triggers for managing migraines.

Insomnia is a sleep disorder characterized by difficulty falling asleep, staying asleep, or getting quality sleep. The cause of insomnia determines how one treats insomnia.

Insomnia isn't just about tossing and turning the whole night and being unable to sleep. It manifests through several key symptoms that disrupt the natural sleep-wake cycle of your body.

Managing rheumatoid arthritis requires different approaches to reduce inflammation and improve the quality of life. While conventional treatments like medications and physical therapy are commonly prescribed, natural remedies can complement these methods effectively.