The 4 Stages of Rheumatoid Arthritis

What Are the Four Stages of Rheumatoid Arthritis?

Rheumatoid arthritis (RA) is a chronic autoimmune disease that mistakenly causes the body’s immune system to attack healthy joint tissue. Unlike regular arthritis that results from wear and tear, RA causes inflammation in the lining of your joints, leading to pain, swelling, stiffness, and, over time, joint damage. 

But RA doesn’t happen overnight. It progresses through defined stages, each with its signs, symptoms, and implications. Understanding these stages can help people with RA take early action, manage symptoms better, and preserve their quality of life.

This is the beginning of the disease, and it’s often the hardest to diagnose. The symptoms at this point can mimic many other conditions. There’s inflammation in the joint lining (synovium), but no visible joint damage on X-rays or scans yet.

Symptoms may include:

• Joint stiffness (especially in the morning)

• Mild swelling

• Fatigue

• Occasional pain in smaller joints like fingers or wrists

At this stage, catching RA early is key. The sooner treatment starts, the better the chances of slowing down or halting progression. Blood tests for markers like rheumatoid factor (RF) or anti-CCP antibodies, along with imaging, can help support a diagnosis.

In this stage, the inflammation begins to affect cartilage, which is the tissue that cushions your joints. You may start seeing visible signs of joint damage in imaging studies, even though the joints are still structurally intact.

Symptoms include:

• Persistent joint pain

• Swelling and warmth around joints

• Reduced range of motion

• Morning stiffness lasting longer than an hour

People often experience difficulty with daily tasks like gripping objects, climbing stairs, or typing. This is when joint function starts to get compromised. Treatment often includes disease-modifying antirheumatic drugs (DMARDs), lifestyle changes, and possibly physical therapy to preserve mobility.

By this point, RA is actively damaging not just the cartilage but also the bones and joint structures. The inflammation has become more aggressive, leading to deformities and functional limitations.

Symptoms include:

• Visible joint deformities (such as fingers bending abnormally)

• Noticeable loss of strength

• Increased pain and swelling

• Muscles around joints may begin to weaken or shrink (atrophy)

Stage 3 is where disability may begin to set in if the disease is not well-managed. Joint damage is often irreversible at this point, which makes ongoing care and timely intervention critical. Medications are typically more aggressive, and pain management becomes a central part of the treatment plan.

In the final stage, the joint is severely damaged, and inflammation may decrease, but this isn’t a sign of improvement. Rather, the joint has deteriorated to the point that function is significantly lost. Cartilage is gone, bones may fuse (a condition called ankylosis), and scar tissue may replace the normal joint structures.

Symptoms include:

• Minimal or no joint function

• Severe pain, even at rest

• Stiffness that limits movement almost entirely

• Potential need for joint replacement surgery or mobility aids

At this stage, quality of life is significantly affected. However, supportive therapies, assistive devices, and surgical options like joint replacement can still improve comfort and functionality.

RA is not a uniform disease and its progression varies from person to person. Some people may remain in early stages for years, while others progress more rapidly. Early detection and aggressive management in Stage 1 can slow or even prevent progression to Stage 4. This includes regular monitoring, medication adherence, anti-inflammatory diets, stress management, and physical activity suited to your ability. 

Cannabinoid-based medications have shown promise in managing pain, reducing inflammation, improving sleep, and supporting emotional regulation - all of which are critical in the day-to-day experience of living with RA. By interacting with the body’s endocannabinoid system, these compounds may offer a multi-targeted and gentler approach. RA may not be curable, but with the right approach, it’s absolutely manageable.

Read more:

• What is Rheumatoid Arthritis?

• What is Arthritis?

• The Role of Diet and Exercise in Managing Arthritis